�Elevated cholesterol levels return to normal or near normal levels over time in four-spot out of 10 children with uncontrollable epilepsy treated with the high-fat ketogenic diet, according to results of a Johns Hopkins Children's Center study reported in the Journal of Child Neurology. The bailiwick appears online ahead of print here.
In the four-year study, the Hopkins Children's team followed 121 epileptic children with intractable seizures on the high-fat, low-carbohydrate ketogenic diet designed to control such seizures. While most children developed high cholesterol after starting the diet, cholesterin gradually improved in about half of them, reverting to normal or near-normal levels, with or without modifications to their diet to decoct fat intake.
In fact, researchers point out, diet modifications-including reducing total fat content or certain types of fats called saturated fats and adding nutritional supplements-reduced high cholesterol just as much as doing naught. High cholesterol is defined as tote up cholesterol greater than two hundred mg per deciliter of blood, bad or LDL (low-density lipoprotein) cholesterol greater than 130, triglycerides greater than cxxx, and good or HDL (high-density lipoprotein) lower than 35.
Researchers prescribed dietary modifications to increment "good," polyunsaturated fats in the diets of 15 children with elevated cholesterol. Dietary modifications decreased cholesterol by 20 percent in 9 tabu of the 15 (60 percent) children whose diets were limited. Surprisingly, cholesterin also dropped by at least 20 percent in 41 pct of the 37 children whose diets remained unchanged. The findings, while encouraging overall, besides mean that relying on diet changes alone may not do much for those children in whom cholesterol stiff persistently exalted, and that new approaches for these patients are needed, researchers say.
The findings should come as consoling news to pediatric neurologists, general pediatricians and parents of children treated with the ketogenic diet, and reassure them that, in most patients, increases in cholesterol may be short-lived, researchers say. Previous semipermanent studies by the Hopkins group of children world Health Organization were on the diet between six and 12 years echoed these findings. The ketogenic diet, believed to work by triggering biochemical changes that winnow out seizure-provoking short-circuits in the brain's sign system, is used in many children with hard-to-control epilepsy and in those whose seizures do non respond to traditional anticonvulsant drug medications.
"We are greatly bucked up by our findings because the near half of the children on the diet were either able-bodied to preserve healthy cholesterin or bit by bit metabolized the extra fat and returned to somewhat normal cholesterol levels," says senior detective Eric Kossoff, M.D., a pediatric brain doctor at Hopkins Children's. "This means the benefits of the diet-a diet that is lifesaving in many children and therapeutic in most of them-continue to outweigh the risks."
Noting that 40 per centum of children maintained normal cholesterol even after starting the diet, researchers found that children fed a formula-based, liquid-only ketogenic diet were nearly three times less likely to break high cholesterol. Researches property this finding to the nearly zero fat content in commonly used ketogenic diet formulas.
In the group with normal cholesterol, 78 percent of children (31 out of 40) were fed formula-based ketogenic diet. This determination, while requiring further study, points to another possible treatment for high cholesterol, Kossoff says, by shift children with persistently raised cholesterol to formula-based ketogenic diets at least some of the time. The formula-based ketogenic diet contains only tierce the amount of pure fats-the worst kind in terms of cholesterol-of the solid nutrient version of the ketogenic diet. Because doctors hindquarters tweak the ratio of fat vs. carbohydrates depending on each child's severeness of seizures, the investigators examined whether higher-fat versions of the ketogenic diet raised cholesterin additionally, merely found that higher-fat ratio did non make cholesterin worse than a lower-fat ratio.
Some of the other findings:
One-fourth of 121 children had elevated tot up cholesterol before starting the diet, which increased to 60 per centum (59 out of 99 children at follow-up) after the initiation of the diet.
18 percent (22 out of 119) had triglycerides all over 130 before the diet, which increased to 51 percent (49 out of 96) after starting the diet.
19 percent (21 out cx) had bad cholesterol over 130 earlier the diet, which increased to 53 percent (48 out of 93) subsequently starting the diet.
The research was funded in part by the National Institutes of Health. Other Hopkins investigators in the study: Juniad Nizamuddin, B.S., Zahava Turner, R.D., James Rubenstien, M.D., Paula Pyzik, B.A.
Founded in 1912 as the children's hospital of the Johns Hopkins Medical Institutions, the Johns Hopkins Children's Center offers one of the virtually comprehensive pediatric medical programs in the country, treating more than 90,000 children each year. Hopkins Children's is consistently stratified among the top children's hospitals in the nation. Hopkins Children's is Maryland's largest children's hospital and the exclusively state-designated Trauma Service and Burn Unit for paediatric patients. It has recognized Centers of Excellence in 20 paediatric subspecialties, including allergy, cardiology, transplant, neurology, neurosurgery, cystic fibrosis, pulmonary, nephrology, gastroenterology and oncology. For more information, please visit http://www.hopkinschildrens.org/
Source: Katerina Pesheva
Johns Hopkins Medical Institutions
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Friday 5 September 2008
Tuesday 26 August 2008
'Thunder' Rumbles Past Batman With $26M
(Paramount Pictures/Warner Bros. Pictures )
It took four of Hollywood's biggest stars to take down Batman. The DreamWorks-Paramount clowning "Tropic Thunder" � with Ben Stiller, Robert Downey Jr., Jack Black and Tom Cruise � debuted at No. 1 with $26 trillion, bumping "The Dark Knight" to indorsement place subsequently four weekends on tiptop, according to studio estimates Sunday.
The Warner Bros. Batman flick pulled in $16.8 1000000 to raise its total to $471.5 million. "The Dark Knight" passed the original "Star Wars" ($461 billion) and at present stands as No. 2 on the all-time domestic charts, slow only "Titanic" ($600.8 million).
Taking inflation into account, "The Dark Knight" trails both movies in actual tickets sold, however. "The Dark Knight" would need to rank about $900 million to match the number of admissions for "Titanic" and about $1.2 billion to equate "Star Wars."
Warner Bros. expects "The Dark Knight" to top extinct at around $530 zillion domestically, said Dan Fellman, the studio's head of distribution.
"The Dark Knight" managed to fend off another "Star Wars" movie this weekend. The animated narration "Star Wars: The Clone Wars," likewise released by Warner Bros., opened at No. 3 with $15.5 million.
Families made up two-thirds of the audience for "Clone Wars," Fellman said. "Star Wars" creator George Lucas, who has an executive producer credit on "Clone Wars," intended the movie as an introduction to his "Clone Wars" TV show debuting this fall on the Cartoon Network.
"It was targeted to a specific audience for specific reasons," Fellman said. "We accomplished that mission, and it will continue in another medium."
"Tropic Thunder" was the third R-rated comedy to open solidly in recent weeks, following "Pineapple Express" and "Step Brothers." Most summer comedies ar rated PG-13, since an R rating limits the audience by requiring anyone younger than 17 to come with an adult.
R-rated comedy hits tend to open in the $20 million to $30 zillion range, take down than their PG-13 counterparts, but often have a longer ledge life in theaters as audiences scatter the word. R-rated movies such as "The 40-Year-Old Virgin," "Knocked Up" and "Superbad" all opened round those levels and went on to become $100 million hits.
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Saturday 16 August 2008
Download Dobet Gnahore
 Artist: Dobet Gnahore: mp3 download Genre(s): Ethnic Discography:  Ano Neko-Let's Create Together Year: 2004 Tracks: 16 Vocalist, professional dancer, and percussionist Dobet Gnahore has been hailed Africa's preeminent lead on the go up, compared to writing style legends and ethnic ambassadors like Miriam Makeba and Hugh Masakela by her twenties. Brought up in a musical and esthetic conservatory environs, Gnahore's musical talent comes as no surprise. Her sire, Boni Gnahore, a drummer, vocalist, and performer celebrity across the Ivory Coast, was a foundation phallus of the artist colony Village Ki-Yi M'Bock, a community of more than 50 artists from multiple disciplines and backgrounds. Her first base esthetic turn peak came when Gnahore was 12 and proclaimed to her father-God that she wasn't going to schoolhouse any longer, but preferably staying at the colony to see. After years of apprenticeship with some of the continent's most skilful artists, Gnahore came upon a mo turning point. French guitar player Colin Laroche de Feline came to the settlement, his intended three-day call in turning into a three-year residency. Gnahore's and Laroche de Feline's professional and personal lives became woven together, creating a couple called Ano Neko. They fagged significant prison term in both Africa and France (depending on the African political mood) touring and playing. The group's self-titled debut was released in 2004 to enthusiastic critical applaud. Two old age later Ano Neko was invited to join the Putumayo Acoustic Africa circuit, which travelled all over Europe and North America. Gnahore and Laroche de Feline north Korean south Korean won fans and impressed audiences, playacting aboard musical greats Vusi Mahlasela and Habib Koité. Soon to follow was Gnahore's sophomore loss, Na Afriki, which, thanks to her ever so expanding winnow foot, appeared on world music charts like a shot following its button. Laroche de Feline and Gnahore conserve a engaged operation schedule patch living with their girl in the French countryside. Gnahore's ease in a broad array of African musical styles has earned her a reputation as prodigy and natural endowment that will one day help oneself chart the course of action for the genre. |
Mike Patton and Buckethead
Thursday 7 August 2008
Veronicas star rues topless photos
Jessica Origliasso has revealed her shock and distress at the publication of photographs of her on an net porn site.
Origliasso, 23, and her twin Falls Lisa - better known as the Veronicas - are
Monday 30 June 2008
Canadian author's debut novel wins prestigious literary award
The 2008 International IMPAC Dublin Award winner was announced Thursday morning. The £100,000 cash prize (almost $200,000) — the biggest for fiction published in English — goes to Canadian author Rawi Hage for "De Niro's Game," a debut novel about two childhood friends growing up in Beirut who, when they come of age, must decide whether to stay in their troubled city or abandon it for an expatriate existence.
Hage was born in Beirut and lived through nine years of civil war in Lebanon. The book was chosen from 137 titles, nominated by 162 libraries in 45 countries. Past winners include Colm Tóibín for "The Master" and Per Petterson for "Out Stealing Horses."
Michael Upchurch, Seattle Times book critic
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Wednesday 25 June 2008
Stevie Wonder announces European tour
Stevie Wonder announced details of a European tour during a showcase in London today (June 5).
Marking the announcement with a live set at the Hard Rock Caf� it was confirmed that the star will play his first European shows in over a decade this year.
"I am looking forward to performing in these venues in Europe," declared Wonder. "We are going to have some wonderful nights of intimate excitement."
The dates are:
Birmingham NIA (September 8)
Manchester MEN (9)
London O2 Arena (11)
Rotterdam Ahoy (14)
Aalborg Gigantium (17)
Stockholm Globe (19)
Hamar Vikingskipet (20)
Cologne Arena (22)
Mannheim Sap Arena (23)
Munich Olympiahalle (25)
Milan Datchforum (26)
Paris Bercy (28)
To check the availability of Stevie Wonder tickets and get all the latest listings, go to NME.COM/GIGS now, or call 0871 230 1094.
For more on Wonder's lunchtime set stay tuned to NME.COM.
Marking the announcement with a live set at the Hard Rock Caf� it was confirmed that the star will play his first European shows in over a decade this year.
"I am looking forward to performing in these venues in Europe," declared Wonder. "We are going to have some wonderful nights of intimate excitement."
The dates are:
Birmingham NIA (September 8)
Manchester MEN (9)
London O2 Arena (11)
Rotterdam Ahoy (14)
Aalborg Gigantium (17)
Stockholm Globe (19)
Hamar Vikingskipet (20)
Cologne Arena (22)
Mannheim Sap Arena (23)
Munich Olympiahalle (25)
Milan Datchforum (26)
Paris Bercy (28)
To check the availability of Stevie Wonder tickets and get all the latest listings, go to NME.COM/GIGS now, or call 0871 230 1094.
For more on Wonder's lunchtime set stay tuned to NME.COM.
Monday 16 June 2008
Yosefa
Artist: Yosefa
Genre(s):
Retro
Discography:
The Desert Speaks
Year:
Tracks: 12
Paulina Rubio - Rubio Forced To Sit Down With Snapper She Beat Up
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